In this paper, we present a three-dimensional dissipative particle dynamics simulation, which is independent of the initial conditions, for analyzing the wettability on liquid-solid interfaces. The model parameters are constructed based on simulation optimization. The contact angle of a droplet on the solid platforms which possess different surface energy is simulated. By tuning the attractive effects between the platform and the droplet, the contact angles are found at steady states. Moreover, the local density and the equation of state are applied for determining the droplet’s self energy and compressibility. The simulation results will help us to predict the profile and internal physical behavior of a micro-droplet.